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Swine-Like Influenza Virus Infection in a Wisconsin Farm Family

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Swine-Like Influenza Virus Infection in a Wisconsin Farm Family

Auteurs : Richard J. O'Brien [États-Unis] ; Gary R. Noble [États-Unis] ; Bernard C. Easterday [États-Unis] ; Alan P. Kendal [États-Unis] ; D. Michael Shasby [États-Unis] ; Donald B. Nelson [États-Unis] ; Michael A. W. Hattwick [États-Unis] ; Walter R. Dowdle [États-Unis]

Source :

RBID : ISTEX:1C0365D68C48D6A7A8DA44E1F4CA7AF96941E97A

Abstract

In October 1975 an eight-year-old boy living on a swine farm in Wisconsin had an illness characterized by upper respiratory, gastrointestinal, and constitutional symptoms. His illness, which occurred shortly after an outbreak of respiratory illness in the swine on the farm, was diagnosed as swine influenza by serologic studies. Epidemiologic investigation revealed that of seven family members the five who had the closest contact with the swine had antibody to swine influenza virus, although none had a history of illness in October. None of the child's other close contacts, including 24 of his classmates, had antibodies to swine influenza virus. The prevalence of antibody to swine influenza virus in other residents of the community was similar to that found in surveys of other communities: titers of hemagglutination-inhibiting antibody of ⩾1:20 in none of persons younger than 15 years, 3% of those 15–34 years old, 12% of those 35–54, and 88% of those 55 and older. A study of the swine in the area indicated that swine influenza had occurred recently in the swine on the farm where the boy lived but not in the herds of two neighboring farms. It was postulated that the boy's illness and the infection without clinical illness in the other seropositive family members resulted from direct exposure to swine influenza virus that had been shed by the sick swine. There was no evidence that person-to-person transmission of swine influenza-like virus had occurred.

Url:
DOI: 10.1093/infdis/136.Supplement_3.S390


Affiliations:


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<div type="abstract">In October 1975 an eight-year-old boy living on a swine farm in Wisconsin had an illness characterized by upper respiratory, gastrointestinal, and constitutional symptoms. His illness, which occurred shortly after an outbreak of respiratory illness in the swine on the farm, was diagnosed as swine influenza by serologic studies. Epidemiologic investigation revealed that of seven family members the five who had the closest contact with the swine had antibody to swine influenza virus, although none had a history of illness in October. None of the child's other close contacts, including 24 of his classmates, had antibodies to swine influenza virus. The prevalence of antibody to swine influenza virus in other residents of the community was similar to that found in surveys of other communities: titers of hemagglutination-inhibiting antibody of ⩾1:20 in none of persons younger than 15 years, 3% of those 15–34 years old, 12% of those 35–54, and 88% of those 55 and older. A study of the swine in the area indicated that swine influenza had occurred recently in the swine on the farm where the boy lived but not in the herds of two neighboring farms. It was postulated that the boy's illness and the infection without clinical illness in the other seropositive family members resulted from direct exposure to swine influenza virus that had been shed by the sick swine. There was no evidence that person-to-person transmission of swine influenza-like virus had occurred.</div>
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